Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor
نویسندگان
چکیده
منابع مشابه
Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.
Franz Matschinsky, * Yin Liang, * Prabakaran Kesavan, * Liqun Wang, * Philippe Froguel,t Gilberto Velho,t Daniel Cohen,t M. Alan Permutt,I Yukio Tanizawa,1 Thomas L. Jetton,11 Kevin Niswender,11 and Mark A. Magnuson,, *Department ofBiochemistry and Biophysics, and the Diabetes Research Center, University ofPennsylvania, Philadelphia, Pennsylvania 19104; tCentre d'Etude du Polymorphisme Humain, ...
متن کاملThe glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.
Expression of glucokinase in hepatocytes and pancreatic 6-cells is of major physiologic importance to mammalian glucose homeostasis. Liver glucokinase catalyzes the first committed step in the disposal of glucose, and beta-cell glucokinase catalyzes a rate-limiting step required for glucose-regulated insulin release. The present study reports the expression of glucokinase in rat glucagon-produc...
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The ubiquitin-proteasome system is important to maintain pancreatic β-cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin secretion. Key regulators of the stimulus/secretion cascade seem to be affected by protein misfolding if the proteasome is down-regulated as recently reported in humans with Type 2 diabetes. It remains unknown, however, whether the gluco...
متن کاملA fiber optic sensor for measuring glucose in aqueous solutions
In this paper, the set-up of a multi-mode fiber optic sensor for measuring glucose in aqueous solutions is investigated and evaluated. The basis of this sensor is based on the Fresnel Reflection. In this setup, a helium-neon laser is used as a light source, a fiber optic probe, photocell as detector and a digital multimeter. The statistical analysis of the recorded data shows a highly linear be...
متن کاملReproducibility of glucose measurements using the glucose sensor.
OBJECTIVE Recent studies have confirmed that improved glycemic control decreases the risk of diabetic complications in type 1 and type 2 diabetic patients. The Minimed glucose sensor allows continuous 72-h glucose monitoring and represents a potentially important tool to improve diabetes management. Its use is currently limited to the health care team. Our aim was to evaluate the reproducibilit...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2008
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-008-1183-9